Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Oogenesis

Oogenesis

Oogenesis, the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...

Ovarian Cycle

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...

Hormonal Control of the Ovarian Cycle

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...

Folliculogenesis

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...

Ovaries

Ovaries

The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of cuboidal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synthesis and evaluation of tetrahydroindazole derivatives as sigma-2 receptor ligands.

Bioorganic & medicinal chemistry·2015

Same author

Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents.

Bioorganic & medicinal chemistry letters·2010

Same author

An improved radiosynthesis of [18F]AV-133: a PET imaging agent for vesicular monoamine transporter 2.

Nuclear medicine and biology·2010

Same author

In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)phenylthio)benzenamine) for PET imaging of the serotonin transporter.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2009

Same author

Working Party on Sperm Donation Services in the UK: report and recommendations.

Human fertility (Cambridge, England)·2008

Same author

2-(2'-((Dimethylamino)methyl)-4'-(3-[(18)F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters.

Nuclear medicine and biology·2008

Search research articles

Related Experiment Video

Updated: May 19, 2026

The Chick Chorioallantoic Membrane (CAM) Model as a Tool to Study Ovarian Tissue Transplantation

The Chick Chorioallantoic Membrane (CAM) Model as a Tool to Study Ovarian Tissue Transplantation

Published on: June 23, 2023

Function of ovarian tissue after long-term storage.

Brian Lieberman

Reproductive Biomedicine Online

|August 4, 2012

Summary

Ovarian tissue cryopreservation offers fertility preservation for cancer patients. Recent findings show successful live births from ovarian cortical strips transplanted over seven years prior, advancing fertility restoration options.

Area of Science:

Reproductive medicine
Oncology
Cryobiology

Background:

Fertility preservation is crucial for cancer patients undergoing gonadotoxic treatments.
Ovarian tissue cryopreservation is an established method for fertility restoration.

Purpose of the Study:

To report on the long-term success of ovarian tissue transplantation for fertility restoration.
To highlight advancements in cryopreservation and transplantation techniques.

Main Methods:

Cryopreservation of ovarian cortical tissue.
Transplantation of cryopreserved ovarian cortical strips.
Monitoring of endocrine function and reproductive outcomes.

Main Results:

Successful live births were documented in three women.

More Related Videos

Gene Expression Analyses in Human Follicles

Gene Expression Analyses in Human Follicles

Published on: February 17, 2023

Related Experiment Videos

Last Updated: May 19, 2026

The Chick Chorioallantoic Membrane (CAM) Model as a Tool to Study Ovarian Tissue Transplantation

The Chick Chorioallantoic Membrane (CAM) Model as a Tool to Study Ovarian Tissue Transplantation

Published on: June 23, 2023

Gene Expression Analyses in Human Follicles

Gene Expression Analyses in Human Follicles

Published on: February 17, 2023

Ovarian cortical strips were transplanted more than seven years prior to the reported births.

This demonstrates the long-term viability and functionality of cryopreserved ovarian tissue.

Conclusions:

Ovarian tissue cryopreservation and subsequent transplantation are effective for long-term fertility preservation.
This technique offers a viable option for cancer survivors to achieve biological parenthood.
The study underscores the potential of cryopreserved ovarian tissue for successful pregnancies years after transplantation.