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Neurodevelopment evaluation in children with congenital hypothyroidism by Bayley-III

Mustafa Komur1, Samim Ozen, Cetin Okuyaz

  • 1Department of Pediatric Neurology, Mersin University School of Medicine, Mersin, Turkey. drmustafakomur@yahoo.com

Brain & Development
|August 4, 2012
PubMed

Insights

Congenital hypothyroidism (CH) can lead to developmental delays, even with early treatment. This study found lower cognitive and motor scores in CH patients compared to controls, suggesting intrauterine factors may impact neurodevelopment.

Area of Science:

  • Pediatric Endocrinology
  • Neurodevelopmental Pediatrics
  • Genetics and Rare Diseases

Background:

  • Congenital hypothyroidism (CH) is a primary cause of preventable intellectual disability.
  • Early and effective treatment is crucial for normal neurological development in infants with CH.

Purpose of the Study:

  • To prospectively compare the neurological development of infants with CH to healthy controls.
  • To assess neurodevelopment using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley III).

Main Methods:

  • A case-control study involving 41 infants with CH and 39 healthy controls aged 6-42 months.
  • Neurological development was evaluated using the Bayley III test.
  • Data collected between 2009 and 2011 at Mersin Children Hospital and Mersin University.

Main Results:

  • Children with CH demonstrated significantly lower scores in cognitive, language, and motor domains compared to controls (p<0.05).
  • Treatment initiation dose, treatment duration, hypothyroidism severity, and time to normalize thyroid-stimulating hormone did not significantly affect neurological outcomes.
  • Higher maternal education and increased family income correlated positively with improved language and overall Bayley III scores (except cognitive) in both groups.

Conclusions:

  • Early treatment of CH does not fully prevent neurological developmental deficits, indicating potential intrauterine influences.
  • This is the first case-control study utilizing the Bayley-III score to evaluate neurological development in CH patients.
  • Socioeconomic factors, such as maternal education and income, play a role in language and overall neurodevelopmental outcomes.
Abstract

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