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07:11
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Total synthesis of the proposed structure of cyclic hexadepsipeptide veraguamide A
Dongyu Wang1, Xian Jia, Ao Zhang
1School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Organic & Biomolecular Chemistry
|August 4, 2012
Abstract:
We have developed a practical method to assemble the proposed structure of natural product veraguamide A (1) by first preparing the three key fragments followed by optimization of the macrocyclization site. Although the synthetic product gave similar optical rotation to that reported for natural product, significant differences in the (1)H and (13)C NMR spectra were observed, especially the proton and carbon signals in the two N-MeVal moieties.
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