Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of excluding internal mammary node coverage on musculoskeletal dosimetry in breast radiotherapy.

Clinical and translational radiation oncology·2025
Same author

Reirradiation practices of Radiation Therapists (RePoRT) study.

Technical innovations & patient support in radiation oncology·2025
Same author

Are blood flow and blood volume predictors of localized photosensitizer accumulation in the brain?

Photodiagnosis and photodynamic therapy·2025
Same author

Quantification of the tumour microvascular response to high dose-per-fraction radiotherapy.

Physics in medicine and biology·2025
Same author

Investigating the effects of stereotactic body radiation therapy on pancreatic tumor hypoxia and microvasculature in an orthotopic mouse model using intravital fluorescence microscopy.

Scientific reports·2024
Same author

Glucagon-Like-Peptide-2 Stimulates Lacteal Contractility and Enhances Chylomicron Transport in the Presence of an Intact Enteric Nervous System.

Gastro hep advances·2024

Related Experiment Video

Updated: May 19, 2026

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research
10:25

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

Published on: April 12, 2024

Quantifying tissue microvasculature with speckle variance optical coherence tomography.

Leigh Conroy1, Ralph S DaCosta, I Alex Vitkin

  • 1Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Optics Letters
|August 4, 2012
PubMed
Summary

We developed a 3D imaging technique to analyze blood vessels in vivo. This method quantifies vessel networks, aiding in tumor characterization and treatment monitoring.

More Related Videos

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Related Experiment Videos

Last Updated: May 19, 2026

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research
10:25

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

Published on: April 12, 2024

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Area of Science:

  • Biomedical optics
  • Medical imaging
  • Vascular biology

Background:

  • Accurate visualization and quantification of in vivo vascular networks are crucial for understanding physiological and pathological processes.
  • Current imaging techniques may lack the resolution or quantitative capabilities needed for detailed vascular analysis.
  • Speckle variance optical coherence tomography (svOCT) offers potential for high-resolution, label-free imaging.

Purpose of the Study:

  • To demonstrate high-resolution, three-dimensional optical imaging of in vivo blood vessel networks using speckle variance optical coherence tomography (svOCT).
  • To develop and apply biologically relevant metrics for quantifying vascular networks from svOCT images.
  • To assess the utility of this quantitative imaging approach for characterizing normal and tumor vascular networks and monitoring treatment response.

Main Methods:

  • High-resolution, 3D svOCT was employed for in vivo imaging of vascular networks.
  • Image processing and segmentation techniques were developed to extract quantitative metrics.
  • Key metrics included vascular density, vessel tortuosity, vascular network fractal dimension, and tissue vascularity.
  • The approach was validated in a preclinical animal model, comparing normal and tumor vascular networks.

Main Results:

  • Successfully achieved high-resolution, 3D imaging of in vivo blood vessel networks.
  • Developed and applied novel metrics for quantitative analysis of vascular structure.
  • Demonstrated the ability to differentiate between normal and tumor vascular networks based on quantitative metrics.
  • Showcased the potential for longitudinal monitoring of vascular changes in response to treatment.

Conclusions:

  • svOCT provides a powerful tool for high-resolution, 3D imaging of in vivo vasculature.
  • Quantitative metrics derived from svOCT images offer valuable insights into vascular network characteristics.
  • This approach holds significant promise for preclinical research, diagnostics, and monitoring therapeutic efficacy in vascular-related diseases.