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Updated: May 19, 2026
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Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
[Pulmonary hemorrhage associated with celiac disease]
María Eugenia Testa1, Alberto Maffey, Alejandro Colom
1Centro Respiratorio, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad autónoma de Buenos Aires, Argentina.
Archivos Argentinos De Pediatria
|August 4, 2012
Summary
Idiopathic pulmonary hemosiderosis (IPH) and celiac disease share immune pathways. Diagnosing celiac disease in IPH patients, even without GI symptoms, and implementing a gluten-free diet can improve outcomes.
Area of Science:
- Immunology
- Gastroenterology
- Pulmonology
Background:
- Idiopathic pulmonary hemosiderosis (IPH) is a severe alveolar hemorrhage disease.
- Lane-Hamilton syndrome describes the association between IPH and celiac disease.
- Shared pathogenic immune pathways may link IPH and celiac disease.
Observation:
- Two 13-year-old patients presented with hemoptysis and severe anemia unresponsive to immunosuppressants.
- Neither patient reported gastrointestinal symptoms.
- Positive antibody titers and intestinal biopsy confirmed celiac disease.
Findings:
- Celiac disease should be suspected in patients with diffuse alveolar hemorrhage, irrespective of GI symptoms.
- Early diagnosis of celiac disease is crucial for effective management.
- A gluten-free diet improved IPH symptoms and reduced the need for immunosuppressive therapy.
Implications:
- This case highlights the importance of screening for celiac disease in IPH patients.
- Dietary gluten withdrawal offers a therapeutic strategy for associated celiac disease.
- Integrated management of IPH and celiac disease can lead to better clinical outcomes.
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