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Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Longitudinal study of renal function in systemic sclerosis.

Melissa Caron1, Marie Hudson, Murray Baron

  • 1McGill University, Jewish General Hospital, Room A-725, 3755 Cote Ste Catherine Road, Montreal, Quebec H3T 1E2, Canada.

The Journal of Rheumatology
|August 4, 2012
PubMed
Summary
This summary is machine-generated.

Renal dysfunction is common in systemic sclerosis (SSc), affecting 20% of patients without scleroderma renal crisis (SRC). Kidney function decline in SSc patients is similar to the general population.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Nephrology
  • Rheumatology
  • Systemic Autoimmune Diseases

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by fibrosis, vasculopathy, and immune dysregulation.
  • Renal involvement, particularly scleroderma renal crisis (SRC), is a significant concern in SSc management.
  • Understanding the prevalence and progression of renal dysfunction is crucial for patient prognosis.

Purpose of the Study:

  • To determine the prevalence of renal disease in patients with systemic sclerosis (SSc).
  • To analyze the longitudinal course of renal function over time in SSc patients.
  • To compare renal function decline in SSc patients with and without a history of SRC.

Main Methods:

  • A multicenter, longitudinal study involving 561 SSc patients from the Canadian Scleroderma Research Group registry.
  • Renal function assessed using estimated creatinine clearance rate (eCcr) via the Cockcroft-Gault formula.
  • Statistical models adjusted for patient dropout to analyze longitudinal changes in eCcr.

Main Results:

  • At baseline, 20% of SSc patients had abnormal renal function without a history of SRC, and 5% had a history of SRC.
  • Patients with abnormal baseline renal function showed an annual eCcr decline of -0.89%, similar to those with normal baseline function.
  • SSc patients with a history of SRC exhibited a similar rate of decline, albeit from a lower baseline eCcr.

Conclusions:

  • Renal dysfunction is prevalent in SSc, occurring even in patients without prior SRC.
  • The rate of renal function decline in SSc patients is generally mild and comparable to the general population.
  • These findings offer valuable prognostic insights for clinicians managing SSc patients.