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Related Experiment Video

Updated: May 19, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Chronic hepatitis E after solid organ transplantation.

A de Niet¹, H L Zaaijer, I ten Berge

¹Departments of Gastroenterology & Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

The Netherlands Journal of Medicine

|August 4, 2012

Summary

This summary is machine-generated.

Hepatitis E virus (HEV) can cause chronic hepatitis in immunocompromised patients, particularly organ transplant recipients. Early HEV RNA testing and ribavirin treatment show promise for managing this serious condition.

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Published on: November 7, 2020

Area of Science:

Hepatology
Virology
Immunology

Background:

Hepatitis E virus (HEV) outbreaks are common in developing nations.
HEV genotypes 3 and 4 are increasingly reported in industrialized countries, often linked to swine.
Acute HEV infection can progress to chronic hepatitis and cirrhosis in immunocompromised individuals.

Observation:

Immunocompromised patients, including solid organ transplant recipients, are at risk for chronic HEV.
Antibody responses to HEV may be absent in these patients, necessitating HEV RNA testing.
Elevated liver tests over months in immunocompromised patients warrant HEV investigation.

Findings:

Chronic HEV infection is a significant concern in immunocompromised patients.
Ribavirin demonstrates potential as a treatment for chronic HEV.
A case report highlights successful ribavirin treatment in a renal transplant recipient with chronic HEV.

Implications:

HEV should be considered in the differential diagnosis of chronic hepatitis in immunocompromised patients.
HEV RNA testing is crucial when liver enzymes are persistently elevated.
Further studies are needed to optimize ribavirin therapy duration and assess outcomes in transplant recipients.