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Early clinical implications of microalbuminuria in patients with acute ischaemic stroke

Bang-Hoon Cho1, Joon-Tae Kim, Jane Chang

  • 1Department of Neurology, Chonnam National University Medical School, Dong-ku, Gwangju, Korea.

Postgraduate Medical Journal
|August 4, 2012
PubMed
Abstract

Insights

Microalbuminuria in acute ischemic stroke patients is linked to worse early outcomes, including neurological deterioration and hemorrhagic transformation. This finding highlights microalbuminuria as a potential indicator for adverse events in stroke patients.

Area of Science:

  • Neurology
  • Nephrology
  • Cardiovascular Research

Background:

  • Microalbuminuria is a known risk factor for stroke incidence and mortality.
  • Its association with early clinical and radiological outcomes in acute ischemic stroke remains understudied.

Purpose of the Study:

  • To investigate the association between microalbuminuria and early clinical outcomes in acute ischemic stroke.
  • To assess radiological outcomes in stroke patients with microalbuminuria.

Main Methods:

  • Retrospective study of ischemic stroke patients admitted within 72 hours of symptom onset.
  • Early clinical outcomes assessed by early neurological deterioration (END) and modified Rankin Scale score >2.
  • Radiological outcomes evaluated by hemorrhagic transformation (HT) and lesion changes on diffusion-weighted imaging.

Main Results:

  • Microalbuminuria was present in 38.5% of patients.
  • Microalbuminuria independently associated with END and HT.
  • Urinary albumin/creatinine ratio correlated significantly with white matter hyperintensity grades and types of HT.

Conclusions:

  • Microalbuminuria is associated with worse early clinical and radiological outcomes in acute ischemic stroke.
  • Patients with microalbuminuria experienced higher rates of END and HT.
  • Microalbuminuria may serve as a predictor for adverse outcomes in the early phase of ischemic stroke.

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