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Updated: May 19, 2026

10:35
A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
Published on: April 5, 2018
Zeroing in on ROS1 rearrangements in non-small cell lung cancer
Magda Stumpfova1, Pasi A Jänne
1Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Abstract:
Rimkunas and colleagues report on the development and validation of an immunohistochemical assay evaluating non-small cell lung cancers (NSCLC) for the presence of ROS1 fusions. The diagnostic was validated in a screen of 556 NSCLCs, identifying 9 (1.6%) tumors with oncogenic ROS1 rearrangements. These patients are candidates for ROS1-targeted therapies.

