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Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

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Diabetic Nephropathy01:28

Diabetic Nephropathy

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Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Related Experiment Video

Updated: May 19, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Urinary biomarkers in obstructive nephropathy.

Peter Trnka1, Larissa Ivanova, Michael J Hiatt

  • 1Department of Paediatrics and Child Health, University of Queensland, Brisbane, Australia.

Clinical Journal of the American Society of Nephrology : CJASN
|August 4, 2012
PubMed
Summary
This summary is machine-generated.

Urinary biomarkers like TGFβ and L1CAM can help assess kidney function in children with obstructive nephropathy, aiding in the prediction of chronic kidney disease progression.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Last Updated: May 19, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

  • Pediatric Nephrology
  • Biomarker Discovery
  • Renal Physiology

Background:

  • Obstructive nephropathy is a primary cause of chronic kidney disease (CKD) in children.
  • Assessing the severity of renal impairment and predicting progression to renal failure in these children is challenging.

Purpose of the Study:

  • To evaluate candidate urinary biomarkers for assessing renal impairment in children with posterior urethral valves (PUVs).
  • To determine the correlation of these biomarkers with glomerular filtration rate (GFR).

Main Methods:

  • A case-control study involving 27 children with PUVs and 20 age-matched controls.
  • Measurement of urinary biomarkers, including protein-to-creatinine ratio, aquaporin-2, TGFβ, and L1CAM.
  • Correlation analysis with GFR using receiver-operating characteristic (ROC) curves and regression analyses.

Main Results:

  • Children with PUVs showed higher urinary protein-to-creatinine ratios and altered excretion of aquaporin-2, TGFβ, and L1CAM compared to controls.
  • Urinary TGFβ excretion was inversely correlated with GFR.
  • TGFβ, L1CAM, and protein-to-creatinine ratio demonstrated good performance in identifying low GFR.

Conclusions:

  • Candidate biomarkers are measurable in whole urine and urine exosomes.
  • These biomarkers correlate with GFR in boys with PUVs, offering potential for improved assessment of obstructive nephropathy.