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Association of reduced renal function with hepatitis B virus infection and elevated alanine aminotransferase

Jianfang Cai1, Xiaohong Fan, Lijun Mou

  • 1Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Clinical Journal of the American Society of Nephrology : CJASN
|August 4, 2012
PubMed

Insights

Hepatitis B virus (HBV) infection combined with elevated alanine aminotransferase (ALT) levels is linked to reduced kidney function. HBV infection alone did not show a significant association with chronic kidney disease (CKD).

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • Hepatitis B virus (HBV) infection is clinically associated with kidney disease.
  • Previous studies have not established a clear link between HBV infection and chronic kidney disease (CKD).

Purpose of the Study:

  • To investigate the association between HBV infection and CKD in a large Chinese adult population.
  • To determine if elevated liver enzymes (ALT) modify the relationship between HBV infection and kidney function.

Main Methods:

  • Cross-sectional study of 6854 Chinese adults aged 30-75 years.
  • Assessed serum hepatitis B surface antigen, ALT, creatinine, and urinary albumin/creatinine ratio.
  • Analyzed estimated glomerular filtration rate (eGFR) and CKD risk factors.

Main Results:

  • HBV infection with elevated ALT was associated with reduced eGFR (OR, 4.07; P=0.03).
  • A significant difference in mean eGFR was observed between HBV-infected and non-infected individuals (P=0.002).
  • Neither HBV infection nor elevated ALT was significantly associated with albuminuria or CKD.

Conclusions:

  • Reduced renal function is associated with HBV infection when accompanied by elevated ALT levels.
  • HBV infection alone is not significantly associated with reduced renal function or CKD.
Abstract

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