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Updated: May 19, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
The -2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a meta-analysis
Yonggang Zhang1, Jie Zhang, Lingjun Zeng
1Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Background:
The -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but the results are not conclusive. The aim of this study is to investigate the association between the -2518A/G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis.
Methods:
We searched Pubmed, Embase, CNKI and Wanfang databases, covering all studies until April 29(th), 2011. Statistical analyses were performed using the Revman4.2 and STATA10.0 software.
Results:
A total of 5341 cases and 6075 controls in 13 case-control studies were included in the meta-analysis. The results indicated that the GG homozygote carriers had a 67% increased risk of TB compared with the A allele carriers (GG vs. GA+AA: OR = 1.67, 95%CI = 1.25-2.23, P = 0.0006). In the subgroup analysis by ethnicity, significant elevated risks were found in Asians and Latinos, but not in Africans (GG vs. GA+AA: OR = 1.79, 95%CI = 1.19-2.70 and P = 0.005 for Asians; OR = 2.15, 95%CI = 1.32-3.51 and P = 0.002 for Latinos; OR = 1.28, 95%CI = 0.45-3.64 and P = 0.65 for Africans).
Conclusion:
This meta-analysis suggested that the -2518A/G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans.
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