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Updated: May 19, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
Adenosine A(2A) Receptor Antagonists and Parkinson's Disease
Brian C Shook1, Paul F Jackson
1Johnson & Johnson Pharmaceutical Research and Development, L.L.C. , Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477, United States. bshook@its.jnj.com
Abstract:
This Review summarizes and updates the work on adenosine A(2A) receptor antagonists for Parkinson's disease from 2006 to the present. There have been numerous publications, patent applications, and press releases within this time frame that highlight new medicinal chemistry approaches to this attractive and promising target to treat Parkinson's disease. The Review is broken down by scaffold type and will discuss the efforts to optimize particular scaffolds for activity, pharmacokinetics, and other drug discovery parameters. The majority of approaches focus on preparing selective A(2A) antagonists, but a few approaches to dual A(2A)/A(1) antagonists will also be highlighted. The in vivo profiles of compounds will be highlighted and discussed to compare activities across different chemical series. A clinical report and update will be given on compounds that have entered clinical trials.
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