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Related Concept Videos

Crossover Experiments01:16

Crossover Experiments

Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
The Scientific Method in Nursing Process01:18

The Scientific Method in Nursing Process

The scientific method provides the foundation for any research. It is the most reliable and objective of all forms of gaining knowledge and guides in applying research-based evidence in practice and conducting future research.
When using research findings to change practice, one must understand the process used to guide a study. The scientific method is a systematic, step-by-step process that supports the data's validity, reliability, and generalizability. As a result, findings can be safely...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Data Collection by Experiments

Data collection is a systematic method of obtaining, observing, measuring, and analyzing accurate information. An experimental study is a standard method of data collection that involves the manipulation of the samples by applying some form of treatment prior to data collection. It refers to manipulating one variable to determine its changes on another variable. The sample subjected to treatment is known as “experimental units.”
An example of the experimental method is a public clinical trial...

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Related Experiment Video

Updated: May 19, 2026

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
07:37

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

Published on: November 17, 2017

Research from the bedside to the lab bench & back.

Robert A White1, Michael Silvey, Derek P Logsdon

  • 1Department of Biochemistry, Kansas City University of Medicine and Biosciences, USA. jtolley@kcumb.edu

Missouri Medicine
|August 7, 2012
PubMed
Summary

Transgenic mice are valuable tools in biomedical research for identifying disease genes and understanding physiological changes. This article showcases promising mouse models for human diseases, aiding research translation to patient benefits.

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Area of Science:

  • Biomedical Research
  • Genetics
  • Animal Models

Background:

  • Transgenic mice offer a powerful system for studying gene function in vivo.
  • Understanding gene manipulation is crucial for disease research and therapeutic development.

Purpose of the Study:

  • To present examples of innovative transgenic mouse models for human diseases.
  • To highlight the role of these models in accelerating biomedical research translation.

Main Methods:

  • Utilizing transgenic technology to create mouse models with specific genetic modifications.
  • Observing and analyzing physiological and pathological changes in these animal models.

Main Results:

  • Demonstrated the utility of transgenic mice in uncovering gene functions related to disease.
  • Showcased specific mouse models that closely mimic human disease phenotypes.

Conclusions:

  • Transgenic mouse models are essential for advancing our understanding of human diseases.
  • These models facilitate the translation of basic research findings into clinical applications, improving patient outcomes.