Related Experiment Video
Updated: May 19, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Prolonged jaundice in neonates
Siba Prosad Paul1, Valerie Hall, Timothy Mackford Taylor
1Great Western Hospital, Swindon.
Insights
Jaundice in newborns is common, especially in breastfed infants. This study found breastfeeding is the primary cause of prolonged jaundice, suggesting reduced referrals and investigations for well infants.
Area of Science:
- Neonatal Medicine
- Pediatrics
- Public Health
Background:
- Jaundice is a frequent condition in newborns, often prompting parental consultation with healthcare providers.
- Up to 40% of breastfed infants exhibit jaundice at 14 days, leading to referrals for pediatric assessment.
- Many referrals reveal elevated bilirubin without other liver abnormalities, diagnosing breastfeeding jaundice.
Purpose of the Study:
- To evaluate current clinical practices regarding neonatal jaundice.
- To identify breastfeeding as a primary cause of prolonged neonatal jaundice.
- To provide guidance for community health practitioners to reduce unnecessary referrals and invasive investigations.
Main Methods:
- Clinical audit of current practices for neonatal jaundice assessment.
- Analysis of referral patterns and investigation results for jaundiced neonates.
- Review of diagnostic criteria for breastfeeding jaundice.
Main Results:
- Breastfeeding was confirmed as the predominant reason for prolonged jaundice in neonates.
- Most infants diagnosed with breastfeeding jaundice required only reassurance and monitoring.
- Current practices may lead to over-referral and unnecessary investigations for otherwise healthy jaundiced infants.
Conclusions:
- Breastfeeding jaundice is a common and benign condition in newborns.
- Community health practitioners can be guided to reduce referrals for well neonates with jaundice.
- Minimizing invasive investigations can improve patient outcomes and healthcare efficiency.
Abstract:
Jaundice is common in neonates and is often the reason for a parent to consult a community midwife or health visitor. It is known that up to 40 per cent of breastfed infants are jaundiced at 14 days of age and a proportion of these infants are referred to paediatric services for assessment and blood investigations. Most often the investigations reveal a high bilirubin level but otherwise normal liver function results, leading to a diagnosis of breastfeeding jaundice, with no treatment required other than reassurance to the parents and monitoring. A recent clinical audit is presented which evaluates current clinical practice and the results reflect breast feeding as the main reason for prolonged jaundice. This is followed by some guidance for the community health practitioners with the aim of reducing referral of otherwise well neonates with jaundice and reducing invasive investigations.
Related Concept Videos
Jaundice
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Inborn Errors of Metabolism
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
