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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Overview
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

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Related Experiment Video

Updated: May 19, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

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Published on: December 15, 2011

Tomato contact dermatitis.

Evy Paulsen1, Lars P Christensen, Klaus E Andersen

  • 1Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark. evy.paulsen@ouh.regionsyddanmark.dk

Contact Dermatitis
|August 7, 2012
PubMed
Summary
This summary is machine-generated.

Contact dermatitis from tomato plants is uncommon but documented. Studies show a 9% positive rate in patch testing, indicating occasional sensitization to tomato plants and fruits.

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Area of Science:

  • Dermatology
  • Allergology
  • Botany

Background:

  • Immediate hypersensitivity reactions to tomato fruits are common.
  • Contact dermatitis from tomato plants and fruits is infrequently reported.
  • Solanum lycopersicum is a globally significant agricultural crop.

Purpose of the Study:

  • To investigate and report new data on contact sensitization to tomato plants.
  • To review existing literature on contact dermatitis linked to tomato plants and fruits.
  • To evaluate the diagnostic methods for tomato-induced contact dermatitis.

Main Methods:

  • Patch testing with ether extracts of tomato plants (oleoresin) was conducted between 2005 and 2011.
  • Literature review on contact dermatitis associated with tomatoes.
  • Analysis of potential allergens in tomato plants and fruits.

Main Results:

  • Nine percent (8 of 93) of patients tested positive for tomato plant oleoresin.
  • Tomato plants are confirmed as occasional sensitizers, aligning with prior research.
  • Tomato fruits can cause protein contact dermatitis, potentially due to fragrance compounds and proteins.

Conclusions:

  • Contact dermatitis from tomato plants is a recognized, albeit rare, condition.
  • Both heat-stable and heat-labile allergens may be involved in plant sensitization.
  • Diagnosis can be aided by ether extracts for plants and fresh fruits for fruit-related dermatitis.