Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to: A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome: Regarding: MOGAD is the Most Common Cause of Isolated Optic Neuritis in Children.

Annals of clinical and translational neurology·2026
Same author

Rates of assaults among New York City Transit workers before and during the COVID-19 pandemic, 2018 - 2023.

Research square·2026
Same author

Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential.

Cell host & microbe·2026
Same author

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children.

Annals of clinical and translational neurology·2026
Same author

Precision cardiovascular risk prediction in type 1 diabetes: An IMI2 SOPHIA analysis.

Nature communications·2026
Same author

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques.

The Journal of clinical investigation·2026

Related Experiment Video

Updated: May 19, 2026

High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

Functional genomic and high-content screening for target discovery and deconvolution.

Susanne Heynen-Genel1, Lars Pache, Sumit K Chanda

  • 1Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

Expert Opinion on Drug Discovery
|August 7, 2012
PubMed
Summary

Functional genomic screens identify new drug targets using automated microscopy. Careful interpretation of results is crucial, integrating data with validation for robust drug discovery.

More Related Videos

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Related Experiment Videos

Last Updated: May 19, 2026

High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Area of Science:

  • Genomics
  • Cell Biology
  • Drug Discovery

Background:

  • Functional genomic screens leverage human genome sequencing for rapid gene identification.
  • Advances in molecular biology and automation enable these powerful screening methods.
  • Image-based high-content screening enhances target acquisition for drug discovery.

Purpose of the Study:

  • To review the utility and challenges of functional genomic screening.
  • To discuss considerations for high-content screening in genomics.
  • To provide examples illustrating these approaches.

Main Methods:

  • Review of functional genomic screening methodologies.
  • Discussion of high-content screening principles and applications.
  • Analysis of technical, experimental, and computational factors.

Main Results:

  • Functional genomic and high-content screening are valuable for identifying novel drug targets.
  • Screening results are significantly influenced by technical and computational parameters.
  • Isolated screening data requires cautious interpretation.

Conclusions:

  • Genomic screens are integral to target identification campaigns.
  • Orthogonal data acquisition and rigorous validation are essential.
  • Strategic integration of screening data enhances drug discovery efficacy.