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Pyrazine derivatives: a patent review (2008 - present)
Sabrina Baptista Ferreira1, Carlos Roland Kaiser
1Universidade Federal do Rio de Janeiro, Chemistry Institute, Department of Organic Chemistry, 27930-560, Mácae-RJ, Brazil.
Expert Opinion on Therapeutic Patents
|August 7, 2012
Summary
Pyrazine derivatives are versatile heterocyclic compounds with diverse pharmacological properties. This review highlights patented pyrazine derivatives from 2008-2012, showcasing their potential in various therapeutic applications.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- Pyrazine derivatives are nitrogen-containing heterocyclic compounds with natural occurrence.
- They can be synthesized through various established methods.
- A significant number of pyrazine derivatives exhibit diverse pharmacological activities, driving research interest.
Purpose of the Study:
- To comprehensively review pyrazine derivatives patented between 2008 and 2012.
- To identify potential active compounds within this class.
- To consolidate information on pyrazine derivative research within a specific patent period.
Main Methods:
- Comprehensive literature and patent search.
- Utilized SciFinder and esp@cenet databases for patent retrieval.
- Included information from published scientific articles.
Main Results:
- Identified numerous pyrazine derivatives patented for their potential as active compounds.
- Covered the period from 2008 to 2012, with additional information up to the present.
- Highlighted the broad spectrum of applications explored in patents.
Conclusions:
- The natural diversity and pharmacological potential of pyrazines continue to stimulate research.
- Patented pyrazine derivatives show promise for antibacterial, antifungal, anticancer, antiviral, and anti-inflammatory applications.
- Further research is needed to rationalize biological activities and develop clinically relevant compounds.
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