Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Detailed Structure and Function of Lymph Nodes

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Functions of the Lymphatic and Immune System

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

Introduction to Lymphatic and Immune System

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...

Lymphatic Vessels and Lymph Transport

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study.

Journal of neuro-oncology·2019

Same author

The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep.

PloS one·2017

Same author

Investigation of intra-herd spread of Mycobacterium caprae in cattle by generation and use of a whole-genome sequence.

Veterinary research communications·2017

Same author

Bloodstream infection in paediatric cancer centres--leukaemia and relapsed malignancies are independent risk factors.

European journal of pediatrics·2015

Same author

Stromal cells as trend-setters for cells migrating into the lymph node.

Mucosal immunology·2014

Same author

Treatment of recurrent primitive neuroectodermal tumors (PNET) in children and adolescents with high-dose chemotherapy (HDC) and stem cell support: results of the HITREZ 97 multicentre trial.

Journal of neuro-oncology·2014

Same journal

PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis.

Clinical and experimental immunology·2026

Same journal

Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India.

Clinical and experimental immunology·2026

Same journal

Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies.

Clinical and experimental immunology·2026

Same journal

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026

Same journal

Clinical, genetic, and functional characterization of novel NFKB1 variants in Chinese patients with primary immunodeficiency.

Clinical and experimental immunology·2026

Same journal

Bispecific MASP-2/3 antibody provides superior renoprotection over monotherapy in pristane-induced lupus nephritis.

Clinical and experimental immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 19, 2026

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

Lymph node dissection--understanding the immunological function of lymph nodes.

M Buettner¹, U Bode

¹Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. buettner.manuela@mh-hannover.de

Clinical and Experimental Immunology

|August 7, 2012

Summary

This summary is machine-generated.

Lymph node (LN) dissection is a key experimental method to study immune responses. This technique reveals the critical role of LNs in initiating immunity, regulating immune responses, and inducing tolerance.

More Related Videos

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

Related Experiment Videos

Last Updated: May 19, 2026

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

Area of Science:

Immunology
Surgical Pathology
Regenerative Medicine

Background:

Lymph nodes (LNs) are crucial sites for initiating immune responses against pathogens.
Understanding LN function is vital for immunology and regenerative medicine research.
Experimental models utilize LN dissection to investigate lymphatic system dynamics.

Purpose of the Study:

To highlight research areas employing LN dissection as an experimental tool.
To elucidate the role of LNs in immune response initiation, regulation, and tolerance.
To analyze cell populations within the lymphatic system and lymph vessel regeneration.

Main Methods:

The review focuses on the experimental surgical technique of lymph node (LN) dissection in various animal models.
LN dissection allows detailed analysis of incoming lymph cell subsets.
This method is used to study regeneration, immunological analysis, and clinical questions.

Main Results:

LN dissection facilitates the detailed analysis of cell subsets within the lymph.
LNs are confirmed as sites for the induction and regulation of antigen-specific immune responses.
LN function is critical for host defense during bacterial infection and for inducing tolerance to harmless antigens.

Conclusions:

Lymph node dissection is an effective method for studying immune responses, tolerance, and infection.
The technique is instrumental in understanding the multifaceted roles of LNs in the immune system.
LN function is essential for both fighting infections and maintaining self-tolerance.