Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genetically engineered mesenchymal stromal cells in cancer gene therapy.

Bratislavske lekarske listy·2018

Same author

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia.

International journal of nanomedicine·2017

Same author

Exosomes of human mesenchymal stem/stromal/medicinal signaling cells.

Neoplasma·2017

Same author

Dental pulp mesenchymal stem/stromal cells labeled with iron sucrose release exosomes and cells applied intra-nasally migrate to intracerebral glioblastoma.

Neoplasma·2016

Same author

Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation.

Neoplasma·2009

Same author

Presence of serum carbonic anhydrase autoantibodies in patients relapsed after autologous stem cell transplantation indicates an improved prognosis.

Neoplasma·2008

Search research articles

Related Experiment Video

Updated: May 19, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Stem cell based glioblastoma gene therapy.

C Altaner¹, V Altanerova

¹Cancer Research Institute SAS, Bratislava, Slovakia. exonalt@savba.sk

|August 7, 2012

Summary

Mesenchymal stem cells engineered to target glioblastoma may offer a curative approach. Preclinical studies show these modified stem cells can attack glioblastoma stem cells, paving the way for clinical trials.

Area of Science:

Oncology
Regenerative Medicine
Gene Therapy

Background:

Glioblastoma multiforme (GBM) remains incurable with current therapies.
Tumor-initiating glioblastoma cells drive the fatal nature of the disease.
Mesenchymal stem cells' tumor-tropic ability presents a potential therapeutic delivery system.

Purpose of the Study:

To review the current knowledge on stem cell-directed glioblastoma therapy.
To explore the potential of mesenchymal stem cells in targeting glioblastoma stem cells.
To discuss immunotherapy modalities using mesenchymal stem cells for glioblastoma.

Main Methods:

Review of preclinical studies on mesenchymal stem cells engineered with suicide genes.
Analysis of stem cell-based gene therapy, specifically cytosine deaminase expression.

More Related Videos

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

Related Experiment Videos

Last Updated: May 19, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

Discussion of immunotherapeutic approaches using mesenchymal stem cells.

Main Results:

Engineered mesenchymal stem cells showed significant antitumor responses in preclinical glioblastoma models.
Mesenchymal stem cells expressing cytosine deaminase demonstrated potential to target glioblastoma stem cells.
Preclinical data indicate stem cell-based gene therapy may be curative.

Conclusions:

Stem cell-based gene therapy, particularly prodrug strategies, shows promise for glioblastoma.
Mesenchymal stem cells offer a viable platform for targeted glioblastoma treatment.
Encouraging preclinical results warrant the initiation of clinical studies for stem cell-directed glioblastoma therapy.