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Intravenous sulprostone infusion in the treatment of retained placenta
Vedran Stefanovic1, Jorma Paavonen, Mikko Loukovaara
1Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland. vedran.stefanovic@hus.fi
Objective:
To analyze the effectiveness of intravenous sulprostone infusion for the treatment of retained placenta without massive primary hemorrhage among women at an university hospital over a three-year period.
Design:
Retrospective observational study.
Setting:
University teaching hospital.
Population:
126 consecutive women with placental retention and intravenous sulprostone infusion as primary treatment performed from October 2007 up to December 2011.
Methods:
Hospital records of women who received sulprostone infusion to attempt placental expulsion were reviewed.
Main Outcome Measures:
Primary endpoints of the study were expulsion of placenta and the total amount of blood loss during delivery.
Results:
The placenta was successfully expelled in 39.7% of cases, whereas 60.3% of women underwent manual removal of placenta. Blood loss was significantly lower in women with successful placental expulsion than in women who had manual removal of the placenta (582 ± 431 ml vs. 1275 ± 721 ml, p < 0.0001). Sulprostone infusion did not cause adverse effects or significant postpartum morbidity.
Conclusions:
Intravenous sulprostone infusion is safe and reduces both blood loss and the need for manual removal of the placenta.
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