Related Experiment Video
Updated: May 19, 2026
10:33
Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages
Published on: October 25, 2017
Interactions of pathogen-containing compartments with the secretory pathway
Johnathan Canton1, Peter E Kima
1Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA.
Cellular Microbiology
|August 7, 2012
Summary
Intracellular pathogens form pathogen-containing compartments (PCCs) that interact with host cell vesicles. This review explores how PCCs engage with the secretory pathway, revealing preferential interactions with specific compartments.
Area of Science:
- Cell Biology
- Microbiology
- Pathogen-Host Interactions
Background:
- Intracellular pathogens reside in membrane-bound pathogen-containing compartments (PCCs).
- PCCs navigate host cell vesicles, modulating interactions with the endocytic pathway.
- The secretory pathway's role in PCC interactions is less understood but shows differential engagement.
Purpose of the Study:
- To review current knowledge on pathogen-containing compartment interactions with the secretory pathway.
- To discuss molecular mechanisms and metabolic benefits of these interactions.
- To highlight preferential interactions between PCCs and specific secretory pathway compartments.
Main Methods:
- Literature review focusing on prokaryote pathogens and protozoan parasites.
- Analysis of existing data on PCC interactions with secretory pathway organelles.
- Synthesis of information on molecular interactions and metabolic advantages.
Main Results:
- PCCs exhibit variable but distinct interactions with the secretory pathway.
- Evidence suggests preferential engagement with specific secretory pathway compartments.
- Molecular interactions and metabolic benefits are key factors in these associations.
Conclusions:
- Pathogen-containing compartments (PCCs) strategically interact with the host cell's secretory pathway.
- These interactions are compartment-specific, suggesting tailored pathogen strategies.
- Understanding these interactions is crucial for deciphering pathogen survival and replication.
Related Concept Videos
01:17Role of ER in the Secretory Pathway
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
01:31Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
01:25Colonisation of Pathogens
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
01:20Infection
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
01:38Receptor-mediated Endocytosis
Overview
01:20Receptor-mediated Endocytosis
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...