Related Experiment Video
Updated: May 19, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease
Ajay Nehra1, Graham Jackson, Martin Miner
1Department of Urology, Mayo Clinic, Rochester, MN 55905, USA. Ajay_Nehra@rush.edu
Insights
The Princeton Consensus updated guidelines for evaluating cardiovascular risk in men with erectile dysfunction (ED). It emphasizes using exercise testing to ensure safety before ED treatment and highlights ED as a potential CVD indicator.
Area of Science:
- Cardiology
- Sexual Medicine
- Preventive Cardiology
Background:
- The Princeton Consensus is a collaborative effort focused on sexual function and cardiovascular health.
- The third conference convened to address cardiovascular risk assessment in men with erectile dysfunction (ED).
Framework:
- Objective 1: Evaluate and manage cardiovascular risk in men with ED and no known cardiovascular disease (CVD), identifying those needing further cardiac evaluation.
- Objective 2: Reevaluate and update recommendations for assessing cardiac risk during sexual activity in men with established CVD.
Implementation:
- Recommendations emphasize exercise testing to match cardiovascular health with the physical demands of sexual activity before ED treatment.
- Highlighting the association between ED and potentially asymptomatic CVD, promoting cardiovascular risk reduction.
Implications:
- Updated guidelines aid clinicians in managing men with ED, integrating sexual health and cardiovascular risk assessment.
- Promotes early identification of CVD in men with ED, potentially preventing adverse cardiovascular events.
Abstract:
The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The third Princeton Consensus met November 8 to 10, 2010, and had 2 primary objectives. The first objective focused on the evaluation and management of cardiovascular risk in men with erectile dysfunction (ED) and no known cardiovascular disease (CVD), with particular emphasis on identification of men with ED who may require additional cardiologic work-up. The second objective focused on reevaluation and modification of previous recommendations for evaluation of cardiac risk associated with sexual activity in men with known CVD. The Panel's recommendations build on those developed during the first and second Princeton Consensus Conferences, first emphasizing the use of exercise ability and stress testing to ensure that each man's cardiovascular health is consistent with the physical demands of sexual activity before prescribing treatment for ED, and second highlighting the link between ED and CVD, which may be asymptomatic and may benefit from cardiovascular risk reduction.
Related Concept Videos
Atherosclerosis III: Management
Endocarditis III: Medical Management
Peripheral Artery Disease III: Interprofessional Care
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Angina IV: Management
Rheumatic Heart Disease III: Medical Management