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Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing

Matthew Cooper1, Maurizio Salvadori, Klemens Budde

  • 1Division of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA. mcooper@smail.umaryland.edu

Transplantation Reviews (Orlando, Fla.)
|August 7, 2012
PubMed

Insights

Enteric-coated mycophenolate sodium (EC-MPS) offers a safer alternative to mycophenolate mofetil (MMF) for renal transplant patients, reducing gastrointestinal issues without compromising efficacy in preventing rejection or graft loss.

Area of Science:

  • Nephrology
  • Immunosuppression
  • Transplantation

Background:

  • Mycophenolate mofetil (MMF) improves renal transplant outcomes but causes gastrointestinal (GI) complications.
  • These GI issues can necessitate dose reduction, risking patient outcomes.
  • Enteric-coated mycophenolate sodium (EC-MPS) provides equivalent mycophenolic acid (MPA) exposure to MMF.

Purpose of the Study:

  • To review the efficacy of EC-MPS versus MMF in renal transplant patients.
  • To assess EC-MPS's impact on biopsy-proven acute rejection and graft loss.
  • To examine EC-MPS use in intensified dosing and calcineurin inhibitor minimization regimens.

Main Methods:

  • Review of clinical studies comparing EC-MPS and MMF in renal transplantation.
  • Analysis of outcomes including acute rejection rates and graft survival.
  • Evaluation of EC-MPS in novel immunosuppressive strategies.

Main Results:

  • EC-MPS demonstrates comparable efficacy to MMF in preventing acute rejection and graft loss.
  • EC-MPS potentially reduces the gastrointestinal burden associated with MMF.
  • EC-MPS is suitable for use in advanced immunosuppressive protocols.

Conclusions:

  • EC-MPS is an effective and potentially better-tolerated alternative to MMF for renal transplant recipients.
  • EC-MPS maintains patient safety and graft outcomes while mitigating GI side effects.
  • EC-MPS offers flexibility in optimizing immunosuppression in renal transplantation.

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