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Profile of sight-threatening infectious keratitis: a prospective study
Ahmad M Otri1, Usama Fares, Mouhamed A Al-Aqaba
1Division of Ophthalmology and visual sciences, Queens Medical Centre, Nottingham, UKDepartment of Ophthalmology, Aleppo University Hospital, Aleppo University, Aleppo, Syria.
Acta Ophthalmologica
|August 7, 2012
Summary
This study identifies key risk factors for microbial keratitis, including ocular surface disease and contact lens wear. Corneal grafting proved effective for severe infections, highlighting its role in managing sight-threatening ulcers.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Microbial keratitis is a significant cause of ocular morbidity.
- Identifying predisposing factors and causative organisms is crucial for effective management.
Purpose of the Study:
- To prospectively investigate sight-threatening corneal ulcers.
- To identify predisposing factors, causative organisms, clinical signs, and treatment outcomes.
Main Methods:
- Prospective study of infective keratitis cases over 3 years.
- Data collection included etiology, culture results, clinical signs, treatment, and patient response.
- Statistical analysis was performed on collected data.
Main Results:
- 143 eyes from 129 patients were enrolled.
- Key risk factors included ocular surface disease (32%), contact lens wear (26%), and prior ocular surgery (20%).
- Staphylococcus aureus, Acanthamoeba, and Pseudomonas aeruginosa were common pathogens; 8.3% required corneal grafting.
Conclusions:
- Microbial keratitis is a major cause of vision loss.
- Previous ocular disease is a significant predisposing factor.
- Corneal grafting is an effective treatment for persistent microbial keratitis.
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