Related Experiment Video

Updated: May 19, 2026

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
08:07

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry

Published on: May 19, 2020

[The role of major histocompatibility complex in the progression of HIV infection]

André Silva-Pinto1, Maria Lurdes Santos

  • 1Serviço de Doenças Infecciosas, Hospital de São João, Porto, Portugal.

Acta Medica Portuguesa
|August 7, 2012
PubMed
Abstract

Insights

Certain individuals with HIV do not progress to AIDS due to specific Human Leukocyte Antigen (HLA) types. HLA-B, particularly HLA-B27 and B57, plays a key role in controlling HIV infection progression.

Area of Science:

  • Immunogenetics
  • Virology
  • Human Genetics

Context:

  • A subset of HIV-infected individuals naturally controls viral progression without antiretroviral therapy.
  • Understanding the host genetic factors influencing HIV disease progression is crucial for developing novel therapeutic strategies.

Purpose:

  • To review the literature on the role of the Major Histocompatibility Complex (MHC) in HIV infection progression.
  • To identify specific Human Leukocyte Antigen (HLA) alleles associated with slower HIV disease progression.

Summary:

  • This review highlights the significant role of Human Leukocyte Antigen (HLA) class I molecules, especially HLA-B, in modulating HIV infection progression.
  • Specific HLA alleles, including HLA-B27 and HLA-B57, are associated with non-progression to Acquired Immunodeficiency Syndrome (AIDS).
  • Amino acid variations within HLA molecules are linked to effective HIV management.

Impact:

  • Identifies key genetic markers (HLA alleles) for predicting HIV disease course.
  • Suggests that HLA-peptide interactions are critical for controlling HIV.
  • Provides a foundation for future research aimed at leveraging genetic insights for HIV treatment strategies.

More Related Videos

Peptide-based Identification of Functional Motifs and their Binding Partners14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview