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Related Concept Videos

Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...

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Related Experiment Video

Updated: May 19, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilic esophagitis].

Mariana Couto1, Susana Rodrigues, Susana Piedade

  • 1Serviço de Imunoalergologia, Hospital São João, Porto, Portugal.

Acta Medica Portuguesa
|August 7, 2012
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis (EE) is an esophageal disease marked by eosinophil buildup, often linked to food allergies. Early diagnosis and treatment involving diet or medication are crucial for managing this condition.

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Last Updated: May 19, 2026

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Area of Science:

  • Gastroenterology and Immunology
  • Inflammatory Bowel Diseases

Context:

  • Eosinophilic esophagitis (EE) is a growing cause of esophageal dysfunction, mimicking GERD but unresponsive to acid suppressants.
  • It frequently co-occurs with food allergies and atopic conditions.
  • EE affects both children and adults, presenting diagnostic challenges due to non-specific symptoms and findings.

Purpose:

  • To review current understanding and guidelines for eosinophilic esophagitis (EE).
  • To propose a diagnostic and therapeutic algorithm for EE management.
  • To emphasize the importance of early recognition and multidisciplinary collaboration.

Summary:

  • EE involves eosinophilic infiltration of the esophageal mucosa, causing dysfunction.
  • Diagnosis requires high suspicion as pathognomonic signs are absent.
  • Treatment strategies include dietary modifications and pharmacotherapy based on allergen sensitization.

Impact:

  • Facilitates timely diagnosis and appropriate therapy for EE.
  • Highlights the need for collaboration between gastroenterologists and immunoallergologists.
  • Provides a framework for managing this chronic, relapsing esophageal condition.