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Restricted spirometry in the Burden of Lung Disease Study
D M Mannino1, M A McBurnie, W Tan
1Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA. dmannino@uky.edu
Summary
Restricted spirometry, a common lung function abnormality, is prevalent in population studies, particularly in women. This finding is linked to higher rates of chronic conditions like diabetes and hypertension.
Area of Science:
- Pulmonary Medicine
- Epidemiology
- Public Health
Background:
- Traditionally, diagnosing restrictive lung disease required measuring total lung capacity, limiting its assessment in large population studies.
- This study explores an alternative method for identifying restriction using spirometry data.
Purpose of the Study:
- To assess the prevalence of restricted spirometry in the Burden of Lung Disease (BOLD) Study.
- To determine the association between restricted spirometry and demographic factors.
- To investigate the relationship between restricted spirometry and chronic diseases such as diabetes, hypertension, and cardiovascular disease.
Main Methods:
- Utilized spirometric data from the BOLD Study to classify individuals with restricted spirometry (FEV(1)/FVC ≥ 0.70 and FEV(1) < 80% predicted).
- Analyzed demographic factors and the presence of chronic diseases in relation to restricted spirometry findings.
Main Results:
- Restricted spirometry was found in 11.7% of men and 16.4% of women, with significant site-to-site variation.
- Individuals with restricted spirometry showed a higher prevalence of diabetes (12.2%), heart disease (15.0%), and hypertension (38.8%) compared to those with normal lung function.
Conclusions:
- Restricted spirometry is a frequent observation in population-based studies.
- Further research is necessary to understand the underlying mechanisms and develop interventions for restricted spirometry.
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