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Age effect on subcortical structures in healthy adults.

Matt Goodro¹, Mohammad Sameti, Brian Patenaude

¹Neurobehavioral Research, Inc., 1585 Kapiolani Blvd, Ste 1030, Honolulu, HI 96814, USA.

Psychiatry Research

|August 7, 2012

Summary

Brain structure volumes change with age. Older adults showed stronger age-related volume changes in specific subcortical brain regions like the ventricles and hippocampus compared to middle-aged adults.

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Published on: February 14, 2014

Area of Science:

Neuroimaging
Human Anatomy
Gerontology

Background:

Subcortical brain structures are crucial for various cognitive functions.
Understanding age-related changes in these structures is vital for identifying neurological health.
Previous research has indicated structural brain changes occur with aging.

Purpose of the Study:

To investigate cross-sectional age effects on eight subcortical brain structures.
To analyze age-related volume changes in normal control volunteers.
To compare age effects between different adult age groups.

Main Methods:

Magnetic resonance imaging (MRI) was used to scan 226 control subjects aged 19-85 years.
Subcortical structure volumes (lateral ventricles, thalamus, caudate, putamen, pallidum, hippocampus, amygdala, nucleus accumbens) were estimated using automated FSL FIRST software.
Data were acquired using 1.5 T and 3.0 T MRI systems.

Main Results:

Significant age-related volume changes were observed in all eight analyzed subcortical structures.
Older subjects (60-85 years) exhibited a stronger correlation between age and volume for ventricles, hippocampus, amygdala, and nucleus accumbens.
Age effects in middle-aged subjects were consistent across different MRI scanner types, supporting methodological validity.

Conclusions:

Age significantly impacts the volume of multiple subcortical brain structures.
The rate of age-related structural volume change may accelerate in older adulthood for specific regions.
The automated neuroimaging analysis methods employed are reliable for studying age-related brain changes.