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Vitamin D in children with cystic fibrosis

Malcolm Brodlie1, William A Orchard, Gordon A Reeks

  • 1Paediatric Respiratory Secretaries, Old Children's Outpatients Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK. m.j.brodlie@ncl.ac.uk

Archives of Disease in Childhood
|August 7, 2012
PubMed

Insights

Increased vitamin D supplementation significantly improved 25-hydroxyvitamin D levels in cystic fibrosis children. However, many pancreatic insufficient children still did not reach the recommended target levels.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Cystic Fibrosis Research

Background:

  • The Cystic Fibrosis Trust established a 2007 target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD).
  • A 2008 audit revealed only 10% of pancreatic insufficient (PI) cystic fibrosis children met this target.

Purpose of the Study:

  • To assess the impact of increased vitamin D supplementation on 25-OHD levels in PI children.
  • To evaluate 25-OHD levels in pancreatic sufficient (PS) children in 2010.

Main Methods:

  • PI children (≥1 year) under sole-care received significantly increased Vitamin D3 supplementation (>450%).
  • Supplementation regimens included 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets.
  • Pancreatic sufficient (PS) children were audited separately in 2010.

Main Results:

  • The median 25-OHD level in PI children rose from 51.5 nmol/L in 2008 to 72 nmol/L in 2010 (p<0.0001).
  • The percentage of PI children achieving >75 nmol/L increased from 10% in 2008 to 51% in 2010.
  • In 2010, 87% of PS children (n=15) had 25-OHD levels below 75 nmol/L.

Conclusions:

  • A substantial increase in vitamin D supplementation significantly improved 25-OHD levels in PI cystic fibrosis children.
  • Despite the increase, approximately half of the PI children did not reach the recommended 75 nmol/L target.
  • The majority of PS children had insufficient 25-OHD levels, indicating a broader issue.
Abstract

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