Related Experiment Video
Updated: May 19, 2026
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
PLA nanoparticles coated with a β-cyclodextrin polymer shell: preparation, characterization and release kinetics of a
Amani El Fagui1, Catherine Amiel
1Institut de Chimie et des Matériaux Paris Est, UMR 7182 CNRS, Université Paris Est, Equipe Systèmes Polymères Complexes, 2-8 rue Henri Dunant, 94320 Thiais, France.
Abstract:
The aim of this work was to incorporate a hydrophobic compound benzophenone (BP) into core-shell nanoparticles (NPs) and to study its release. The core of these NPs is based on polylactic acid (PLA) and serves as a nanocontainer to accommodate BP. The shell is constituted of a β-cyclodextrin polymer (Poly-β-CD) which ensures the control of BP release through non-covalent host-guest interactions. Studies were focused on the preparation, physico-chemical analysis of the BP-loaded NPs and on the elucidation of the release mechanisms. The main features which are the slow kinetics, the dilution-induced release and the total release of encapsulated BP are in good agreement with a mechanism mainly controlled by diffusion of BP and by its binding with the β-CDs cavities present at the surface of NPs.
