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Related Experiment Video

Updated: May 19, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Transfusion-associated necrotizing enterocolitis: evidence and uncertainty.

Sheila M Gephart1

  • 1College of Nursing, University of Arizona, Tucson, USA. sgephart@nursing.arizona.edu

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses
|August 7, 2012
PubMed
Summary

Transfusion-associated necrotizing enterocolitis (TANEC) is linked to 25-35% of necrotizing enterocolitis (NEC) cases in preterm infants. Further research is needed to confirm if holding feedings during transfusions can prevent TANEC.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Transfusion Medicine

Background:

  • Transfusion-associated necrotizing enterocolitis (TANEC) is a serious complication occurring within 48 hours of blood transfusion in neonates.
  • TANEC is associated with 25-35% of necrotizing enterocolitis (NEC) cases, particularly in vulnerable preterm infants.
  • Current evidence is primarily from observational, retrospective studies, highlighting a need for higher-quality research.

Purpose of the Study:

  • To review the current understanding of TANEC, including its association with NEC.
  • To identify risk factors and clinical characteristics of infants developing TANEC.
  • To explore potential preventative strategies, such as modifying feeding practices during transfusions.

Main Methods:

  • Review of existing observational and retrospective studies on TANEC.
  • Analysis of clinical data on infants who developed TANEC, focusing on prematurity, illness severity, and age at onset.
  • Synthesis of evidence regarding the impact of holding feedings during transfusions.

Main Results:

  • Infants developing TANEC are typically smaller, born preterm, more severely ill, and diagnosed with NEC after 30 days of age.
  • Limited evidence from two studies suggests that withholding enteral feedings during blood transfusions may be protective.
  • The overall evidence base for TANEC is limited, necessitating more rigorous investigation.

Conclusions:

  • TANEC is a significant concern in neonatal care, linked to a substantial proportion of NEC cases.
  • While preliminary evidence suggests holding feedings during transfusions might be beneficial, robust clinical trials are required.
  • Further high-quality research, including prospective randomized controlled trials, is crucial to establish optimal management strategies for TANEC prevention.