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Prognostic value of cardiac-specific troponins in intracranial hemorrhage
Ashraf S Abdo1, Stephen A Geraci
1Medical Science Department, GV (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA. ashraf.abdo@va.gov
Insights
Cardiac-specific troponin (Tn) elevations may associate with outcomes in patients with intracerebral hemorrhage. However, current data are insufficient to confirm consistent predictive value for prognosis.
Area of Science:
- Cardiology
- Neurology
- Clinical Biomarkers
Background:
- Cardiac-specific troponin (Tn) is a key marker for acute myocardial infarction.
- Elevated Tn levels in noncardiac conditions like intracerebral hemorrhage (ICH) may offer prognostic insights.
- Understanding Tn's role in ICH is crucial for patient outcome prediction.
Purpose of the Study:
- To systematically review the literature on cardiac-specific troponin (Tn) levels and clinical outcomes in patients with intracerebral hemorrhage (ICH).
- To assess the potential prognostic value of Tn elevations in the context of ICH.
Main Methods:
- A systematic review of English-language medical literature was conducted using PubMed.
- Inclusion criteria focused on articles reporting original data relevant to Tn levels and outcomes in ICH patients.
Main Results:
- Ten studies were included in the review.
- Cardiac abnormalities were observed in some patients with elevated Tn, but not consistently.
- While some studies indicated worse outcomes with elevated Tn, findings were inconsistent across the literature.
Conclusions:
- An association between cardiac-specific Tn elevations and clinical events in ICH patients is suggested by the literature.
- Current data are insufficient to establish a consistent predictive value of Tn for prognosis in ICH.
- Routine Tn monitoring for prognosis in ICH is not recommended at this time due to insufficient evidence.
Background:
Cardiac-specific troponin (Tn) serum concentrations have proved to be important diagnostic and prognostic markers for acute myocardial infarction. Elevated levels in the setting of noncardiac diseases such as intracerebral hemorrhage also may provide useful prognostic information regarding outcome.
Methods:
A systematic review of the English-language medical literature was performed using PubMed. Articles reporting original data were included.
Results:
Ten reports qualified for review. A spectrum of cardiac abnormalities was observed in studied patients, sometimes more frequently in those with Tn elevations, whereas some had no such abnormalities, even if Tn was detected. Although some studies suggested a worse outcome in patients with elevated Tn levels, the findings were inconsistent.
Conclusions:
At this time, although the literature suggests an association between cardiac-specific Tn elevations and clinical events in patients with intracranial hemorrhage, data are insufficient to conclude that there is a consistent predictive value or to recommend routine Tn monitoring for prognosis.
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