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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Metabolites from the mangrove-derived fungus Xylaria cubensis PSU-MA34
Saranyoo Klaiklay1, Vatcharin Rukachaisirikul, Yaowapa Sukpondma
1Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Abstract:
Two new succinic acid derivatives, xylacinic acids A (1) and B (2), along with seven known compounds, including one succinic acid derivative (3), three mellein derivatives (4-6), cytochalasin D (7), 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (8) and isosclerone (9), were isolated from the mangrove-derived fungus Xylaria cubensis PSU-MA34. Their structures were established by spectroscopic evidence. They were evaluated for cytotoxicity against KB cells and antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus.
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