Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenanthrenoids and oxoaporphine alkaloids from <i>Monoon fuscum</i> B. Xue & R.M.K. Saunders and their biological activities.

Natural product research·2026
Same author

Synthetic Strategies for Mono-Carbonyl Curcumin Analogues: Reaction Optimisation, Substituent Influence, and Emerging Sustainable Methods.

Current organic synthesis·2026
Same author

In vivo screening of Thai plant extracts for antithrombocyte activity using zebrafish: discovery of novel antiplatelet compounds.

Fitoterapia·2026
Same author

Phytochemical study of Fissistigma fulgens (Hook.f. & Thomson) Merr. leaves: Previously undescribed dihydrochalcone derivatives and their biological activities.

Phytochemistry·2025
Same author

Abietane diterpenoids and their biological activities from Premna herbacea Roxb.

Phytochemistry·2025
Same author

Network pharmacology and metabolomics reveal mathurameha, a Thai traditional Anti-Diabetic formula, enhances glucose metabolism through PI3K-AKT/AMPK/GLUT4 pathway modulation.

Scientific reports·2025

Related Experiment Video

Updated: May 19, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

Antibacterial compounds from Zanthoxylum rhetsa.

Cholpisut Tantapakul1, Wong Phakhodee, Thunwadee Ritthiwigrom

  • 1Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.

Archives of Pharmacal Research
|August 7, 2012
PubMed
Summary

A new amide, zanthorhetsamide, was isolated from Zanthoxylum rhetsa. Dihydrochelerythrine showed potent antibacterial activity against resistant Staphylococcus aureus and moderate activity against Escherichia coli.

Related Experiment Videos

Last Updated: May 19, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Zanthoxylum rhetsa is a plant species known for its traditional medicinal uses.
  • Natural products from plants are a rich source of potential therapeutic agents.
  • Investigating the chemical constituents and bioactivity of Zanthoxylum rhetsa can lead to new drug discoveries.

Purpose of the Study:

  • To isolate and characterize chemical compounds from the roots and stem barks of Zanthoxylum rhetsa.
  • To evaluate the antibacterial activity of the isolated compounds.

Main Methods:

  • Extraction of compounds from Zanthoxylum rhetsa roots and stem barks.
  • Structure elucidation using spectroscopic methods (e.g., NMR, MS).
  • Antibacterial activity screening using standard assays (e.g., MIC determination).

Main Results:

  • A new amide, zanthorhetsamide (1), was identified along with nine known compounds (2-10).
  • Dihydrochelerythrine (4) demonstrated significant antibacterial activity.
  • MIC values for dihydrochelerythrine (4) were 8 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA) SK1 and 16 μg/mL against Escherichia coli TISTR 780.

Conclusions:

  • Zanthoxylum rhetsa is a source of novel and known bioactive compounds.
  • Dihydrochelerythrine (4) shows promising antibacterial potential, particularly against MRSA.
  • Further research into dihydrochelerythrine (4) could lead to new antibacterial therapies.