Vaccination coverage in children with juvenile idiopathic arthritis followed at a paediatric tertiary care centre

Marie-Paule Morin1, Caroline Quach, Elise Fortin

  • 1Division of Rheumatology, The Montreal Children's Hospital, 2300 Tupper Street, Montreal, Quebec, H3H 1P3, Canada.

Insights

Vaccination coverage in pediatric patients with juvenile idiopathic arthritis (JIA) was suboptimal, with only 61% fully vaccinated by their last visit. Strategies like catch-up immunizations are needed to improve JIA patient vaccination rates.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Public Health

Background:

  • Juvenile idiopathic arthritis (JIA) patients require up-to-date immunizations to prevent infections, especially when on immunosuppressive therapies.
  • Assessing vaccination coverage in this vulnerable population is crucial for guiding public health strategies.

Purpose of the Study:

  • To determine the vaccination coverage rate among JIA patients at a pediatric tertiary care center.
  • To evaluate adherence to the Quebec Immunization Protocol for individual vaccines in JIA patients.

Main Methods:

  • A cohort of 200 JIA patients aged 2-18 years with available immunization records was analyzed.
  • Descriptive statistics assessed complete vaccination status at 2.5, 10.5 years, and the last clinic visit, adhering to the Quebec Immunization Protocol.

Main Results:

  • Complete vaccination was achieved in 52% at 2.5 years, 68% at 10.5 years, and 61% at the last visit.
  • Overall individual vaccine coverage was good, except for measles, mumps, and rubella (MMR) vaccine at 2.5 years (58%).

Conclusions:

  • A significant proportion of JIA patients (39%) lacked complete vaccination status by their last visit.
  • Implementing targeted interventions, such as catch-up vaccination programs, is recommended to improve immunization rates in JIA patients.
Abstract

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...