Pulmonary function as a cause of cognitive aging

Human aging is associated with decline in cognitive and physical functioning. Although pulmonary function predicts long-term performance (up to 10 years) on measures of cognitive function, recent data suggest the opposite relationship: Cognitive decline predicts self-reported physical limitations. In the study reported here, we utilized dual-change-score models to determine the directional relationship between pulmonary and cognitive function. Our sample consisted of 832 participants (ages 50-85 years at baseline), who were assessed in up to seven waves of testing across 19 years as part of the longitudinal Swedish Adoption/Twin Study of Aging. Changes in pulmonary function led to subsequent changes in fluid cognitive function, specifically, in tasks reflecting psychomotor speed and spatial abilities. There was no evidence that declines in cognitive function led to subsequent declines in pulmonary function. Thus, these data indicate a directional relationship from decreased pulmonary function to decreased cognitive function, a finding that underscores the importance of maintaining pulmonary function to ensure cognitive performance.