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Related Experiment Video

Updated: May 19, 2026

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
11:27

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050

Published on: May 13, 2020

Structure-function relationships in human D-amino acid oxidase.

Silvia Sacchi1, Laura Caldinelli, Pamela Cappelletti

  • 1Dipartimento di Biotecnologie e Scienze della Vita, Università degli studi dell'Insubria, via J.H. Dunant 3, 21100 Varese, Italy. silvia.sacchi@uninsubria.it

Amino Acids
|August 7, 2012
PubMed
Summary
This summary is machine-generated.

D-serine, a crucial brain molecule, regulates NMDA receptors. Human D-amino acid oxidase (DAO) is key to D-serine metabolism and a potential therapeutic target for neurological disorders.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • D-serine is an

Purpose of the Study:

  • To provide an overview of human D-amino acid oxidase (DAO)
  • To discuss DAO's role in D-serine metabolism
  • To highlight DAO as a therapeutic target

Main Methods:

  • Biochemical analysis
  • Structural analysis
  • Functional significance assessment

Main Results:

  • DAO is a flavoprotein crucial for D-serine degradation
  • DAO activity and stability influence brain D-serine levels
  • DAO is implicated in neurological conditions

Conclusions:

  • DAO plays a pivotal role in brain D-serine metabolism
  • DAO is a significant target for drug development in neurological diseases
  • Understanding DAO's properties is vital for therapeutic strategies.