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Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic

Sanjeev Kumar Syal1, Aditya Kapoor, Eesh Bhatia

  • 1Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Luck now 226014, India. akapoor65@gmail.com

The Journal of Invasive Cardiology
|August 7, 2012
PubMed

Insights

Vitamin D deficiency is common in Indian patients with coronary artery disease (CAD). Low vitamin D levels are associated with more severe CAD and endothelial dysfunction, impacting cardiovascular health.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to increased risk of coronary artery disease (CAD) and cardiovascular death.
  • Endothelial dysfunction is a key factor in CAD pathogenesis.
  • Limited data exist on vitamin D's role in CAD and endothelial dysfunction among Asian populations.

Purpose of the Study:

  • To investigate the relationship between vitamin D levels, CAD severity, and endothelial function in Indian patients.
  • To assess the prevalence of vitamin D deficiency in patients with angiographically confirmed CAD.

Main Methods:

  • Study included 100 patients undergoing coronary angiography.
  • Measured serum 25-hydroxyvitamin D [25(OH)D] levels.
  • Assessed endothelial function using brachial artery flow-mediated dilation (FMD).

Main Results:

  • 80% of patients had vitamin D deficiency, with 36% severely deficient (<10 ng/mL).
  • Vitamin D deficiency correlated with higher prevalence of multi-vessel CAD and diffuse CAD.
  • Lower 25(OH)D levels were associated with significantly reduced FMD and increased prevalence of endothelial dysfunction.

Conclusions:

  • Vitamin D deficiency is prevalent in Indian patients with CAD.
  • Low vitamin D levels are associated with more severe CAD and impaired endothelial function.
  • Findings highlight the potential role of vitamin D in cardiovascular health and CAD progression.
Abstract

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