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Relationship between leukocytic infiltration and endothelial specialization in murine cardiac allografts
D M Leppink1, D K Bishop, D D Sedmak
1Department of Surgery, Ohio State University College of Medicine, Columbus 43210.
Human Immunology
|December 1, 1990
Abstract:
We have used immunologic and histologic techniques to analyze the rejection of heterotopic murine cardiac allografts. These studies were designed to test the hypothesis that lymph-node-like mechanisms of lymphocyte extravasation develop in immediately vascularized organ allografts during the process of rejection. The experimental results suggest that lymph-node-like mechanisms are not involved, and that an unexpected pattern of lymphocyte infiltration develops in these allografts.