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Reproductive toxicity and histopathological changes induced by lambda-cyhalothrin in male mice
Ali S Al-Sarar1, Yasser Abobakr, Alaa E Bayoumi
1Plant Protection Department, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Environmental Toxicology
|August 7, 2012
Summary
Lambda-cyhalothrin (LCT) insecticide exposure significantly harms male mouse reproductive health, causing reduced sperm counts and increased abnormalities. LCT also induced dose-dependent damage to the liver, kidneys, and spleen.
Area of Science:
- Toxicology
- Environmental Health
- Reproductive Toxicology
Background:
- Lambda-cyhalothrin (LCT) is a widely used pyrethroid insecticide.
- Assessing the toxicological impact of LCT on mammalian systems is crucial.
Purpose of the Study:
- To investigate the reproductive toxicity, hepatotoxicity, nephrotoxicity, and splenotoxicity of Lambda-cyhalothrin in adult male mice.
Main Methods:
- Adult male mice were administered LCT orally at doses of 0.2, 0.4, and 0.8 mg/kg/day for 6 weeks.
- Evaluated seminal vesicle weight, epididymal sperm count, sperm morphology, and motility.
- Conducted histopathological examinations of testes, liver, kidneys, and spleen.
Main Results:
- Significant reduction in seminal vesicle weight observed across all tested doses.
- Decreased epididymal sperm count at the highest dose.
- Reduced live and motile spermatozoa proportions and increased abnormal sperm morphology at medium and high doses.
- Dose-related degenerative damage observed in testes, liver, kidneys, and spleen.
Conclusions:
- Lambda-cyhalothrin exhibits reproductive toxicity in male mice, affecting sperm parameters and reproductive organ weights.
- LCT demonstrated significant hepatotoxicity, nephrotoxicity, and splenotoxicity in a dose-dependent manner.
- These findings highlight the potential health risks associated with LCT exposure.
