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Updated: May 19, 2026

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Published on: November 21, 2017
Poly(2-oxazoline)s as polymer therapeutics
Robert Luxenhofer1, Yingchao Han, Anita Schulz
1Professur für Makromolekulare Chemie, Department Chemie, Technische Universität Dresden, Dresden, Germany. Robert.Luxenhofer@chemie.tu-dresden.de
Abstract:
Poly(2-oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next-generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx-based systems were presented, the field lay dormant for almost two decades. Only very recently, POx-based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx-protein conjugates, POx-drug conjugates, POx-based polyplexes and POx micelles for drug delivery.
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