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Updated: May 19, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Hydrogels incorporating GdDOTA: towards highly efficient dual T1/T2 MRI contrast agents
Thomas Courant1, Valérie Gaëlle Roullin, Cyril Cadiou
1Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Université de Reims Champagne Ardenne, UFR de Pharmacie, Reims, France.
Abstract:
Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA NPs) exhibited high relaxivity (r(1) =101.7 s(-1) mM(-1) per Gd(3+) ion at 37 °C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T(1)/T(2) dual-mode contrast agent was studied in C6 cells.

