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Updated: May 19, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
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A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Does sepsis treatment differ between primary and overflow intensive care units?

Kittane Vishnupriya1, Olufunmilayo Falade, Addisu Workneh

  • 1Department of Medicine, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA. kvishnu1@jhmi.edu

Journal of Hospital Medicine
|August 7, 2012
PubMed
Summary

Sepsis care in overflow intensive care units (ICUs) was similar to primary ICUs, with slightly less deep vein thrombosis and gastrointestinal prophylaxis. Patient outcomes and length of stay were unaffected by overflow care.

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Published on: June 15, 2019

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Hospital Administration

Background:

  • Sepsis is a leading cause of mortality in hospitalized patients.
  • Early goal-directed therapy is the standard of care for sepsis.
  • Overflow intensive care units (ICUs) are utilized when primary ICUs are at capacity.

Purpose of the Study:

  • To compare process-of-care measures for sepsis patients managed in primary versus overflow ICUs.
  • To assess the impact of ICU overflow on sepsis patient management and outcomes.

Main Methods:

  • Retrospective study of adult sepsis patients admitted between July 2009 and February 2010.
  • Comparison of baseline characteristics and process-of-care measures between primary and overflow ICUs.
  • Analysis included diagnostic and therapeutic interventions, and prophylaxis adherence.

Main Results:

  • No significant differences in baseline Acute Physiology and Chronic Health Evaluation (APACHE II) scores between groups.
  • Adherence to deep vein thrombosis (DVT) and gastrointestinal (GI) prophylaxis within 24 hours was lower in overflow ICUs (49% vs 74% for DVT; 44% vs 68% for GI).
  • Hospital and ICU length of stay did not differ significantly between primary and overflow ICUs.

Conclusions:

  • Sepsis patients managed in primary and overflow ICUs received similar care.
  • Transferring sepsis patients to overflow ICUs does not appear to negatively impact guideline-concordant care or length of stay.
  • Ensuring consistent prophylaxis protocols in overflow units may further optimize care.