Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug interactions with quinolones.

R Janknegt1

  • 1Department of Clinical Pharmacology and Toxicology, Maasland Hospital, Sittard, The Netherlands.

The Journal of Antimicrobial Chemotherapy
|November 1, 1990
PubMed
Summary

Fluoroquinolones can interact with other drugs, affecting their efficacy and safety. Avoid co-administration with penicillins, clindamycin, antacids, and certain NSAIDs to prevent adverse effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nocebo effect challenges the non-medical infliximab switch in practice.

European journal of clinical pharmacology·2018
Same author

The use of an electronic clinical rule to discontinue chronically used benzodiazepines and related Z drugs.

European journal of clinical pharmacology·2017
Same author

Usually Available Clinical and Laboratory Data Are Insufficient for a Valid Medication Review: A Crossover Study.

The journal of nutrition, health & aging·2016
Same author

SWAB/NVALT (Dutch Working Party on Antibiotic Policy and Dutch Association of Chest Physicians) guidelines on the management of community-acquired pneumonia in adults.

The Netherlands journal of medicine·2012
Same author

[Optimisation of the antibiotic policy in the Netherlands. X. The SWAB guideline for antimicrobial treatment of complicated urinary tract infections].

Nederlands tijdschrift voor geneeskunde·2006
Same author

[Optimizing the antibiotics policy in The Netherlands. VIII. Revised SWAB guidelines for antimicrobial therapy in adults with community-acquired pneumonia].

Nederlands tijdschrift voor geneeskunde·2005

Area of Science:

  • Pharmacology
  • Drug Interactions

Background:

  • Fluoroquinolones are broad-spectrum antibiotics with significant drug interaction potential.
  • Understanding these interactions is crucial for safe and effective patient management.

Purpose of the Study:

  • To review the pharmacodynamic and pharmacokinetic drug interactions of fluoroquinolones.
  • To identify pharmaceutical incompatibilities and clinical implications.

Main Methods:

  • Literature review of published studies on fluoroquinolone drug interactions.
  • Analysis of reported incompatibilities and pharmacokinetic/pharmacodynamic effects.

Main Results:

  • Incompatibilities observed with penicillins and clindamycin.
  • Inhibition of theophylline and caffeine clearance by certain fluoroquinolones.
  • Reduced absorption of fluoroquinolones by antacids, iron supplements, and sucralfate.
  • Potential interactions with midazolam, opiates, cyclosporine, oral anticoagulants, and NSAIDs.

Conclusions:

  • Clinicians should be aware of potential fluoroquinolone drug interactions.
  • Avoidance of interacting drug combinations is recommended.
  • Further studies are needed for certain interactions, like with midazolam and opiates.

Related Experiment Videos