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Updated: May 19, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Premature delivery and the millennium development goal
1Department of Maternal-Fetal Medicine, Brigham and Women's Hospital, Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School Boston, MA.
Insights
Preterm birth affects 15 million babies annually, causing 1 million newborn deaths. Improving maternal health and prenatal care is crucial to reduce preterm delivery (PTD) rates and child mortality.
Area of Science:
- Global health
- Neonatal health
- Obstetrics
Background:
- Preterm birth (PTD) affects 15 million newborns yearly, causing 1 million deaths and significant long-term disabilities.
- PTD is the leading cause of neonatal mortality and the second leading cause of death in children under five.
- A survival gap exists between high-income and low-resource nations, with over 90% mortality for infants born before 28 weeks in low-resource settings.
Purpose of the Study:
- To highlight the global burden of preterm birth (PTD).
- To identify risk factors associated with PTD.
- To emphasize the need for improved maternal health and prenatal care to achieve global child mortality reduction goals.
Main Methods:
- This study is a review of existing data on preterm birth (PTD) rates and outcomes.
- Analysis of global statistics on neonatal mortality and survival rates based on gestational age and resource setting.
- Identification and categorization of risk factors for PTD.
Main Results:
- Approximately 15 million babies are born prematurely each year worldwide.
- High-income nations have significantly higher survival rates for extremely preterm infants compared to low-resource nations.
- Key risk factors for PTD include adolescent pregnancy, short birth intervals, maternal health conditions, and substance abuse.
Conclusions:
- Reducing preterm birth (PTD) is essential for achieving global child mortality reduction targets (e.g., MDG-4).
- Addressing risk factors and enhancing maternal health and prenatal care quality are critical interventions.
- Closing the survival gap in preterm infants requires targeted global health initiatives.
Abstract:
Worldwide, approximately 15 million babies (1 in 10) are born prematurely each year. Prematurity is the leading cause of death among newborns, accounting for 1 million deaths per year, and, after pneumonia, is the second leading cause of death in children under age 5 years. Newborns who do survive preterm delivery (PTD) struggle with visual, auditory, and learning disabilities. In order to reach the fourth Millennium Development Goal (MDG-4) of reducing the mortality rate in children under age 5 years by two-thirds between 1990 and 2015, there must be significantly fewer PTDs. In high-income nations, 50% of babies born at 24 weeks survive, whereas in low-resource nations, this survival rate is not achieved until 32 weeks of gestation. Over 90% of babies born in low-resource settings before 28 weeks die in the first few days of life (< 10% die in high-income nations), a 10:90 survival gap. Over 60% of PTDs worldwide occur in Sub-Saharan Africa and South Asia. Risk factors for PTD include adolescent pregnancy, short interval between births, poor prepregnancy weight (very low or high body mass index), chronic diseases (diabetes and hypertension), infectious disease, substance abuse, cervical incompetence, and poor psychological health. Thus, a commitment to improving maternal health and the quality of prenatal care is necessary to achieve the MDG-4.
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