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Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin
Published on: April 29, 2016
Relationship of epidermal melanocytes and langerhans cells with epidermal cambial cells
T M Yavisheva1, S D Shcherbakov, I S Golubeva
1NN Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, Russia. javisheva@rambler.ru
Abstract:
Studies of mouse ear epidermis showed that proliferative activity of basal epidermal cells has two active and two passive phases throughout 24 h. Active phases consist of two subphases: long (proliferation of cambial cell descendants) and very short (cambial cell proliferation). Cambial cells proliferate at the boundary between active and passive phases; this results in an increase in the counts of epidermal melanocytes and Langerhans cells resultant from division of epidermal cambial cells. The count of Langerhans cells almost 2-fold surpasses melanocyte count, because melanocytes gradually transform into epidermal basal cells.
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