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Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during
T I Bondarenko1, I A Sorokina, E A Mayboroda
1Southern Federal University, Rostov-on-Don, Russia. tomabon@yandex.ru
Abstract:
Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen>myocardium>testicles>liver>skeletal muscles) has been demonstrated. Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific. Delta sleep-inducing peptide exhibited a hypoglycemic effect: it prevented nonenzymatic glycosylation of hemoglobin and reduced the level of defective protein molecules during aging.
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