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Updated: May 19, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Hippo inactivation feeds tumor-initiating cells

Stephan Duss, Adrian Britschgi, Mohamed Bentires-Alj

    Breast Cancer Research : BCR
    |August 8, 2012
    PubMed

    Insights

    The Hippo pathway, a tumor suppressor, regulates cell growth. Researchers linked TAZ, a Hippo pathway component, to breast cancer stem cell traits, epithelial-to-mesenchymal transition, and cell polarity.

    Area of Science:

    • Cell biology
    • Molecular oncology
    • Cancer research

    Background:

    • The Hippo pathway is a conserved kinase cascade regulating cell proliferation and survival.
    • It functions as a critical tumor suppressor pathway.
    • Dysregulation of the Hippo pathway is implicated in various cancers.

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