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Maternal dehydration: impact on ovine amniotic fluid volume and composition.
P Schreyer1, D J Sherman, M G Ervin
1Perinatal Research Laboratories, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90502.
Journal of Developmental Physiology
|May 1, 1990
Summary
Maternal dehydration increases plasma osmolality and arginine vasopressin (AVP) in both mother and fetus. This leads to reduced amniotic fluid volume and increased concentrations of electrolytes, potentially causing oligohydramnios.
Area of Science:
- Perinatal physiology
- Reproductive biology
- Maternal-fetal medicine
Background:
- Maternal dehydration causes hyperosmolality and increased arginine vasopressin (AVP).
- Reduced fetal urine and lung fluid production are linked to dehydration or exogenous AVP.
- Amniotic fluid volume and composition may be affected by maternal dehydration.
Purpose of the Study:
- To investigate the effects of maternal dehydration on amniotic fluid volume and composition in pregnant ewes.
Main Methods:
- Six pregnant ewes were water-deprived for 54 hours.
- Maternal and fetal plasma, and amniotic fluid parameters were measured.
Main Results:
- Maternal and fetal plasma osmolality and AVP levels significantly increased.
- Amniotic fluid osmolality and sodium/potassium concentrations rose.
- A significant 35% reduction in amniotic fluid volume was observed.
Conclusions:
- Maternal dehydration significantly impacts maternal-fetal-amniotic fluid dynamics.
- Dehydration may contribute to the development of oligohydramnios.